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For example, not fully clarified are functions of pleiotropic compounds formed through TRP-KYN pathway, such as kynurenine (KYN), anthranilic acid (ANA), kynurenic acid (KYNA), and quinolinic acid (QA), capable modulate brain and immune system, and which play a role in the pathogenesis of a wide range of illnesses, including cancer, liver cirrhosis, and neurodegenerative and psychiatric diseases, such as dementia, Alzheimers disease, Parkinsons disease, multiple sclerosis, and schizophrenia [2,3]